AZD6738

Across CCLE and GDSC cell-line panels, response to AZD6738 is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible AZD6738 response-associated pathways across cancer lineages are Negative regulation of release of sequestered calcium ion into cytosol, Preganglionic parasympathetic fiber development, and Negative regulation of macrophage chemotaxis, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD6738 response versus Negative regulation of release of sequestered calcium ion into cytosol pathway activity in BONE (Pearson r = -0.75).

Pathway activity biomarkers of AZD6738 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of release of sequestered calcium ion into cytosol →	-0.175	-0.685	.004	.015	3	8
BONE	Preganglionic parasympathetic fiber development →	-0.165	-0.894	.042	.006	3	8
PANCREAS	Negative regulation of macrophage chemotaxis →	+0.111	+0.636	.008	.005	3	7
PANCREAS	Regulation of transforming growth factor beta1 production →	-0.207	-0.657	.004	.001	3	7
LUNG_NSCLC_LUSC	DNA topological change →	+0.135	+1.283	.011	.012	3	7
UPPER_AERODIGESTIVE_TRACT	Epidermal growth factor receptor signaling pathway →	-0.124	-0.577	.009	.027	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD6738 response vs Negative regulation of release of sequestered calcium ion into cytosol — BONE

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