AZD6482

Across CCLE and GDSC cell-line panels, response to AZD6482 is significantly associated with the shRNA dependency of multiple gene dependencies, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible AZD6482 response-associated gene dependencies across cancer lineages are MSMO1, CTIF, and HNRNPA1, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD6482 response versus MSMO1 shRNA dependency in BREAST (Pearson r = -0.44).

Shrna dependency biomarkers of AZD6482 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MSMO1 →	-0.197	-0.801	.002	.014	3	4
SKIN	CTIF →	+0.165	+0.497	.013	.034	3	3
SKIN	HNRNPA1 →	-0.259	-0.410	.009	.029	3	3
SKIN	ACKR2 →	-0.190	-0.400	.019	.025	3	3
SKIN	LRRC3 →	-0.147	-0.662	<.001	.009	3	3
SKIN	GRIK2 →	+0.343	+0.518	.005	.011	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD6482 response vs MSMO1 — BREAST

Explore this scatter interactively →