AZD5582

Across CCLE and GDSC cell-line panels, response to AZD5582 is significantly associated with the shRNA pathway dependency of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible AZD5582 response-associated pathways across cancer lineages are Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, Regulation of hormone biosynthetic process, and Positive regulation of viral entry into host cell, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD5582 response versus Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay shRNA pathway dependency in SKIN (Pearson r = 0.50).

Shrna pathway dependency biomarkers of AZD5582 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay →	+1.286	+0.953	.002	.015	3	7
OVARY	Regulation of hormone biosynthetic process →	-1.218	-1.789	<.001	<.001	3	7
PANCREAS	Positive regulation of viral entry into host cell →	-1.338	-1.341	.023	.002	3	7
PANCREAS	Positive regulation by symbiont of entry into host →	-1.338	-1.341	.023	.002	3	7
BLOOD_Leukemia	Regulation of mitotic cytokinesis →	-0.163	-1.174	.008	.011	3	7
SKIN	DAMP catabolic process →	-1.236	-0.724	.001	.019	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD5582 response vs Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay — SKIN

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