AZD5438

Across CCLE and GDSC cell-line panels, response to AZD5438 is significantly associated with the pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible AZD5438 response-associated pathways across cancer lineages are Mitochondrial L-ornithine transmembrane transport, Mitochondrial gene expression, and Epidermal growth factor receptor signaling pathway, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD5438 response versus Mitochondrial L-ornithine transmembrane transport pathway activity in OVARY (Pearson r = 0.45).

Pathway activity biomarkers of AZD5438 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Mitochondrial L-ornithine transmembrane transport →	+0.196	+1.068	.008	.014	3	10
LUNG_NSCLC_LUSC	Mitochondrial gene expression →	+0.134	+0.810	.012	.046	3	10
BONE	Epidermal growth factor receptor signaling pathway →	-0.091	-0.707	.032	.027	3	9
BONE	Regulation of miRNA metabolic process →	-0.103	-0.822	.005	<.001	3	9
LARGE_INTESTINE	Regulation of TOR signaling →	-0.038	-0.780	.002	.001	3	9
OVARY	Organelle inheritance →	-0.132	-0.943	<.001	.002	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD5438 response vs Mitochondrial L-ornithine transmembrane transport — OVARY

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