AZD4877

Across CCLE and GDSC cell-line panels, response to AZD4877 is significantly associated with the shRNA pathway dependency of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible AZD4877 response-associated pathways across cancer lineages are Negative regulation of osteoclast development, 2'-deoxyribonucleoside catabolic process, and Nucleoside catabolic process, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD4877 response versus Negative regulation of osteoclast development shRNA pathway dependency in OVARY (Pearson r = -0.51).

Shrna pathway dependency biomarkers of AZD4877 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of osteoclast development →	-1.093	-0.668	.019	.042	3	7
CNS	2'-deoxyribonucleoside catabolic process →	+1.237	+0.762	.007	.030	3	7
SKIN	Nucleoside catabolic process →	+0.684	+0.904	.030	.015	3	7
PANCREAS	Production of molecular mediator of immune response →	+0.251	+0.844	.023	.008	3	6
KIDNEY	[2Fe-2S] cluster assembly →	+0.307	+0.809	.002	.008	3	6
LUNG_SCLC	Negative regulation of cGAS/STING signaling pathway →	+0.421	+0.765	.002	.029	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD4877 response vs Negative regulation of osteoclast development — OVARY

Explore this scatter interactively →