AZD4547

Across CCLE and GDSC cell-line panels, response to AZD4547 is significantly associated with the total protein of multiple proteins, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible AZD4547 response-associated proteins across cancer lineages are FRA1, FASN, and ASNS, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD4547 response versus FRA1 total protein in LUNG_NSCLC_LUSC (Pearson r = -0.69).

Total protein biomarkers of AZD4547 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FRA1 →	-1.827	-0.940	.002	.027	3	7
UPPER_AERODIGESTIVE_TRACT	FASN →	+1.482	+0.855	.029	.011	3	6
OVARY	ASNS →	+1.405	+0.764	.010	.007	3	6
SKIN	FOXO3a_pS318_S321 →	-0.139	-0.364	.017	.035	3	6
LUNG_NSCLC_LUSC	GSK-3_pS9 →	-1.324	-0.943	.011	.014	3	5
SOFT_TISSUE	XBP1 →	+0.395	+1.352	.001	.014	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD4547 response vs FRA1 — LUNG_NSCLC_LUSC

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