AZD4547

Across CCLE and GDSC cell-line panels, response to AZD4547 is significantly associated with the protein abundance of multiple proteins, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible AZD4547 response-associated proteins across cancer lineages are ESYT2, TMED7, and FKBP4, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD4547 response versus ESYT2 protein abundance in LIVER (Pearson r = -0.75).

Protein abundance biomarkers of AZD4547 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ESYT2 →	-1.742	-1.032	.003	.004	3	9
BLOOD_Myeloma	TMED7 →	-1.647	-0.785	<.001	.014	3	9
UPPER_AERODIGESTIVE_TRACT	FKBP4 →	+1.251	+0.509	.018	.016	3	8
LARGE_INTESTINE	STIM1 →	-0.834	-1.226	.002	.009	3	8
UPPER_AERODIGESTIVE_TRACT	UBE2R2 →	+1.044	+0.480	.015	.014	3	8
UPPER_AERODIGESTIVE_TRACT	BTF3 →	+0.944	+0.395	.016	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD4547 response vs ESYT2 — LIVER

Explore this scatter interactively →