AZD4547

Across CCLE and GDSC cell-line panels, response to AZD4547 is significantly associated with the response to other drugs of multiple drugs, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible AZD4547 response-associated drugs across cancer lineages are Axitinib, PD173074, and Savolitinib, each associated with drug response in up to 18 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD4547 response versus Axitinib response to other drugs in SOFT_TISSUE (Pearson r = 0.81).

Response to other drugs biomarkers of AZD4547 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner drug	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Axitinib →	+1.664	+1.845	<.001	<.001	3	18
STOMACH	PD173074 →	+1.799	+1.992	.005	.003	3	18
LUNG_NSCLC_LUAD	Savolitinib →	+0.883	+0.916	<.001	<.001	3	18
PANCREAS	GW441756 →	+0.760	+1.046	<.001	<.001	3	17
STOMACH	Foretinib →	+0.981	+1.528	.005	.032	3	17
KIDNEY	Tamoxifen →	+0.868	+0.966	<.001	<.001	3	16

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD4547 response vs Axitinib — SOFT_TISSUE

Explore this scatter interactively →