AZD3759

Across CCLE and GDSC cell-line panels, response to AZD3759 is significantly associated with the mutation status of multiple genes, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible AZD3759 response-associated genes across cancer lineages are CSMD3, OBSCN, and RIMS2, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, AZD3759 response grouped by CSMD3 status in BLOOD_Lymphoma.

Mutation status biomarkers of AZD3759 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CSMD3 →	-1.539	-0.167	.014	.029	3	4
BLOOD_Lymphoma	OBSCN →	-1.539	-0.150	.004	.042	3	3
LUNG_SCLC	RIMS2 →	-2.637	-0.241	.042	.016	3	3
LARGE_INTESTINE	PKD1L1 →	+2.321	+0.432	.007	.015	3	3
LUNG_NSCLC_LUAD	ANKRD17 →	-2.733	-0.544	.043	.035	3	2
BREAST	LRP1B →	-2.724	-0.303	.040	.040	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD3759 response by CSMD3 status — BLOOD_Lymphoma

Explore this box plot interactively →