AZD3759

Across CCLE and GDSC cell-line panels, response to AZD3759 is significantly associated with the protein-level pathway activity of multiple pathways, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible AZD3759 response-associated pathways across cancer lineages are Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, Epiboly, and Epiboly involved in wound healing, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD3759 response versus Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum protein-level pathway activity in BLOOD_Myeloma (Pearson r = -0.65).

Protein-level pathway activity biomarkers of AZD3759 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	-0.303	-0.432	.004	.011	3	7
SOFT_TISSUE	Epiboly →	-0.415	-0.377	.017	.012	3	7
SOFT_TISSUE	Epiboly involved in wound healing →	-0.415	-0.377	.017	.012	3	7
SOFT_TISSUE	Wound healing, spreading of cells →	-0.415	-0.377	.017	.012	3	7
BONE	Protein-DNA complex disassembly →	+0.215	+0.299	.017	.012	3	7
LUNG_SCLC	Regulation of T cell mediated cytotoxicity →	-1.004	-0.377	.001	.005	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD3759 response vs Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum — BLOOD_Myeloma

Explore this scatter interactively →