AZD3514

Across CCLE and GDSC cell-line panels, response to AZD3514 is significantly associated with the pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible AZD3514 response-associated pathways across cancer lineages are Conditioned place preference, Cytoplasmic microtubule organization, and Positive regulation of hydrolase activity, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD3514 response versus Conditioned place preference pathway activity in PANCREAS (Pearson r = 0.46).

Pathway activity biomarkers of AZD3514 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Conditioned place preference →	+0.255	+0.334	.021	.049	3	9
SOFT_TISSUE	Cytoplasmic microtubule organization →	-0.117	-0.519	<.001	.022	3	8
OESOPHAGUS	Positive regulation of hydrolase activity →	-0.059	-0.392	.022	.018	3	7
BLOOD_Myeloma	Intracellular sphingolipid homeostasis →	-0.140	-0.424	.038	.015	3	7
UPPER_AERODIGESTIVE_TRACT	Amyloid precursor protein metabolic process →	-0.143	-0.726	.018	.017	3	7
SKIN	Purine deoxyribonucleoside catabolic process →	+0.847	+0.443	.040	.028	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD3514 response vs Conditioned place preference — PANCREAS

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