AZD2014

Across CCLE and GDSC cell-line panels, response to AZD2014 is significantly associated with the shRNA dependency of multiple gene dependencies, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible AZD2014 response-associated gene dependencies across cancer lineages are WDR92, RAI14, and SLC8B1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD2014 response versus WDR92 shRNA dependency in OESOPHAGUS (Pearson r = 0.58).

Shrna dependency biomarkers of AZD2014 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WDR92 →	+0.219	+0.750	.016	.030	3	7
PANCREAS	RAI14 →	+0.310	+0.867	.019	.027	3	6
OESOPHAGUS	SLC8B1 →	+0.281	+0.981	.001	.007	3	6
LARGE_INTESTINE	BHLHE41 →	+0.343	+1.083	.002	.005	3	6
STOMACH	EIF4E →	+0.437	+0.830	.014	.024	3	6
CNS	ADRB2 →	+0.167	+0.551	.011	.035	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD2014 response vs WDR92 — OESOPHAGUS

Explore this scatter interactively →