AZD2014

Across CCLE and GDSC cell-line panels, response to AZD2014 is significantly associated with the RNA expression of multiple genes, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible AZD2014 response-associated genes across cancer lineages are METTL8, LPIN2, and VEGFB, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD2014 response versus METTL8 RNA expression in OVARY (Pearson r = 0.51).

Rna expression biomarkers of AZD2014 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	METTL8 →	+0.799	+0.853	.003	.009	3	8
OESOPHAGUS	LPIN2 →	-1.851	-0.762	<.001	.003	3	8
OVARY	VEGFB →	-1.109	-1.041	.002	.004	3	8
LIVER	PRLR →	-1.973	-1.250	.042	.007	3	8
URINARY_TRACT	SEC31A →	-0.828	-0.797	.007	.036	3	8
BONE	IFITM10 →	-1.316	-0.424	.040	.012	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD2014 response vs METTL8 — OVARY

Explore this scatter interactively →