AZD1480

Across CCLE and GDSC cell-line panels, response to AZD1480 is significantly associated with the mutation status of multiple genes, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible AZD1480 response-associated genes across cancer lineages are RYR2, TTN, and SCN9A, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, AZD1480 response grouped by RYR2 status in BLOOD_Lymphoma.

Mutation status biomarkers of AZD1480 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RYR2 →	+2.321	+0.340	.013	.045	3	3
OVARY	TTN →	+1.000	+0.351	.032	.029	3	3
LARGE_INTESTINE	SCN9A →	+1.678	+0.431	.029	.018	3	3
BLOOD_Lymphoma	HELZ2 →	+2.900	+0.395	.015	.036	3	2
LUNG_NSCLC_LUAD	KCNB2 →	-3.389	-0.359	.001	.012	3	2
LUNG_NSCLC_LUAD	CRB1 →	+2.678	+0.377	.037	.020	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD1480 response by RYR2 status — BLOOD_Lymphoma

Explore this box plot interactively →