AZD1332

Across CCLE and GDSC cell-line panels, response to AZD1332 is significantly associated with the RNA expression of multiple genes, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible AZD1332 response-associated genes across cancer lineages are DUSP7, ZBTB7B, and AKTIP, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD1332 response versus DUSP7 RNA expression in PANCREAS (Pearson r = 0.34).

Rna expression biomarkers of AZD1332 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DUSP7 →	+1.085	+0.495	.004	.030	3	8
BREAST	ZBTB7B →	-1.128	-0.490	.005	.037	3	8
UPPER_AERODIGESTIVE_TRACT	AKTIP →	-1.242	-1.256	.016	.002	2	9
BLOOD_Lymphoma	TTC7A →	-1.122	-0.669	.041	.035	3	8
LARGE_INTESTINE	ATP6V0E1 →	-0.467	-0.591	.037	.042	2	9
BLOOD_Lymphoma	POGLUT2 →	+1.770	+1.019	.002	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD1332 response vs DUSP7 — PANCREAS

Explore this scatter interactively →