AZD1208

Across CCLE and GDSC cell-line panels, response to AZD1208 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible AZD1208 response-associated genes across cancer lineages are CDH23, AHNAK, and FRAS1, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, AZD1208 response grouped by CDH23 status in LARGE_INTESTINE.

Mutation status biomarkers of AZD1208 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH23 →	+2.295	+0.377	.003	.001	3	3
LARGE_INTESTINE	AHNAK →	+2.125	+0.338	.012	.006	3	3
LARGE_INTESTINE	FRAS1 →	+2.932	+0.315	.009	.015	3	3
LARGE_INTESTINE	TENM2 →	+1.932	+0.304	.036	.015	3	3
LARGE_INTESTINE	DLC1 →	+1.736	+0.252	.025	.045	3	3
STOMACH	DNAH2 →	+2.722	+0.308	.023	.041	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD1208 response by CDH23 status — LARGE_INTESTINE

Explore this box plot interactively →