AZ960

Across CCLE and GDSC cell-line panels, response to AZ960 is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible AZ960 response-associated pathways across cancer lineages are Rostrocaudal neural tube patterning, 'de novo' AMP biosynthetic process, and Heme biosynthetic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZ960 response versus Rostrocaudal neural tube patterning pathway activity in BONE (Pearson r = 0.75).

Pathway activity biomarkers of AZ960 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Rostrocaudal neural tube patterning →	+0.184	+0.462	<.001	.001	3	7
LUNG_SCLC	'de novo' AMP biosynthetic process →	+0.193	+0.690	.002	.004	3	7
OVARY	Heme biosynthetic process →	+0.096	+0.754	.005	.011	3	7
LUNG_NSCLC_LUSC	Primitive hemopoiesis →	+0.164	+0.797	.003	.008	3	7
CNS	CGMP biosynthetic process →	-1.146	-0.504	.007	.014	3	7
LARGE_INTESTINE	Nuclear receptor-mediated signaling pathway →	-0.054	-0.818	.013	.007	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZ960 response vs Rostrocaudal neural tube patterning — BONE

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