AZ6102

Across CCLE and GDSC cell-line panels, response to AZ6102 is significantly associated with the shRNA dependency of multiple gene dependencies, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible AZ6102 response-associated gene dependencies across cancer lineages are PRB3, MUS81, and TNFRSF1A, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZ6102 response versus PRB3 shRNA dependency in PANCREAS (Pearson r = 0.50).

Shrna dependency biomarkers of AZ6102 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRB3 →	+0.231	+0.892	.021	.025	3	7
PANCREAS	MUS81 →	+0.116	+0.520	.026	.009	3	7
LUNG_NSCLC_LUAD	TNFRSF1A →	+0.119	+0.366	.004	.031	3	7
KIDNEY	SKA1 →	-0.460	-0.302	.009	.034	3	6
LIVER	BBOX1 →	-0.254	-0.474	.013	.010	3	6
OVARY	ADAMTS12 →	+0.177	+0.634	.037	.023	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZ6102 response vs PRB3 — PANCREAS

Explore this scatter interactively →