AZ6102

Across CCLE and GDSC cell-line panels, response to AZ6102 is significantly associated with the shRNA pathway dependency of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible AZ6102 response-associated pathways across cancer lineages are Regulation of NMDA receptor activity, Negative regulation of dendritic spine maintenance, and Regulation of transepithelial transport, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZ6102 response versus Regulation of NMDA receptor activity shRNA pathway dependency in PANCREAS (Pearson r = 0.77).

Shrna pathway dependency biomarkers of AZ6102 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of NMDA receptor activity →	+2.053	+0.879	.029	.008	2	8
LIVER	Negative regulation of dendritic spine maintenance →	+0.343	+0.513	.004	.003	3	6
BREAST	Regulation of transepithelial transport →	+0.454	+0.308	.029	.023	3	6
BREAST	G2/M transition of mitotic cell cycle →	-0.348	-0.590	<.001	<.001	3	6
LIVER	Reactive oxygen species metabolic process →	-1.127	-0.513	.032	.003	3	6
LARGE_INTESTINE	Megakaryocyte differentiation →	-0.685	-0.528	.022	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZ6102 response vs Regulation of NMDA receptor activity — PANCREAS

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