AZ20

Across CCLE and GDSC cell-line panels, response to AZ20 is significantly associated with the total protein of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible AZ20 response-associated proteins across cancer lineages are FOXO3a_pS318_S321, c-Myc, and HER3_pY1289, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZ20 response versus FOXO3a_pS318_S321 total protein in LUNG_SCLC (Pearson r = -0.58).

Total protein biomarkers of AZ20 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FOXO3a_pS318_S321 →	-0.253	-0.658	.017	.010	3	7
SOFT_TISSUE	c-Myc →	+0.742	+0.534	.003	.016	3	6
BLOOD_Lymphoma	HER3_pY1289 →	+0.231	+0.486	<.001	.005	3	5
BLOOD_Lymphoma	MEK1 →	-0.669	-0.531	.004	.002	3	5
OVARY	4E-BP1 →	+0.502	+0.312	.042	.044	2	6
BONE	SETD2 →	+0.287	+0.465	.048	.025	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZ20 response vs FOXO3a_pS318_S321 — LUNG_SCLC

Explore this scatter interactively →