AZ20

Across CCLE and GDSC cell-line panels, response to AZ20 is significantly associated with the pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible AZ20 response-associated pathways across cancer lineages are Phospholipid biosynthetic process, Pyrimidine nucleotide metabolic process, and Regulation of DNA replication, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZ20 response versus Phospholipid biosynthetic process pathway activity in LARGE_INTESTINE (Pearson r = -0.38).

Pathway activity biomarkers of AZ20 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Phospholipid biosynthetic process →	-0.028	-0.594	.007	.010	3	10
OVARY	Pyrimidine nucleotide metabolic process →	+0.052	+0.400	.040	.038	2	9
CNS	Regulation of DNA replication →	+0.051	+0.324	.013	.026	2	9
OVARY	Protein targeting to Golgi apparatus →	-0.200	-0.400	.024	.049	3	8
SKIN	Negative regulation of double-strand break repair →	+0.067	+0.363	.002	.015	2	9
SKIN	Negative regulation of DNA repair →	+0.074	+0.456	.001	.002	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZ20 response vs Phospholipid biosynthetic process — LARGE_INTESTINE

Explore this scatter interactively →