AT7867

Across CCLE and GDSC cell-line panels, response to AT7867 is significantly associated with the protein-level pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible AT7867 response-associated pathways across cancer lineages are IRES-dependent viral translational initiation, Ribosomal small subunit assembly, and RNA polymerase I preinitiation complex assembly, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AT7867 response versus IRES-dependent viral translational initiation protein-level pathway activity in LARGE_INTESTINE (Pearson r = 0.60).

Protein-level pathway activity biomarkers of AT7867 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IRES-dependent viral translational initiation →	+0.338	+0.673	<.001	.001	3	10
LARGE_INTESTINE	Ribosomal small subunit assembly →	+0.232	+0.949	<.001	<.001	3	8
BLOOD_Lymphoma	RNA polymerase I preinitiation complex assembly →	+0.247	+0.641	.024	.004	3	8
LARGE_INTESTINE	Negative regulation of striated muscle cell differentiation →	-0.504	-0.573	.009	.017	3	8
LARGE_INTESTINE	Negative regulation of amyloid fibril formation →	+0.586	+0.549	.026	.001	3	8
LARGE_INTESTINE	Viral translation →	+0.378	+0.605	.002	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AT7867 response vs IRES-dependent viral translational initiation — LARGE_INTESTINE

Explore this scatter interactively →