AT-7519

Across CCLE and GDSC cell-line panels, response to AT-7519 is significantly associated with the shRNA dependency of multiple gene dependencies, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible AT-7519 response-associated gene dependencies across cancer lineages are SSR4, NAGPA, and PROP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AT-7519 response versus SSR4 shRNA dependency in STOMACH (Pearson r = -0.75).

Shrna dependency biomarkers of AT-7519 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SSR4 →	-0.262	-1.725	.003	.016	3	7
OVARY	NAGPA →	-0.305	-0.891	.006	.028	3	6
CNS	PROP1 →	-0.309	-1.120	.006	.012	3	6
URINARY_TRACT	TBCE →	+0.465	+1.150	.009	.018	2	7
URINARY_TRACT	MPZ →	+0.233	+1.469	.014	.019	2	7
BLOOD_Myeloma	GALNT5 →	+0.315	+1.094	.007	.025	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AT-7519 response vs SSR4 — STOMACH

Explore this scatter interactively →