AT-7519

Across CCLE and GDSC cell-line panels, response to AT-7519 is significantly associated with the protein-level pathway activity of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible AT-7519 response-associated pathways across cancer lineages are Positive regulation of mitotic cell cycle phase transition, RNA polymerase I preinitiation complex assembly, and Positive regulation of transporter activity, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AT-7519 response versus Positive regulation of mitotic cell cycle phase transition protein-level pathway activity in STOMACH (Pearson r = 0.55).

Protein-level pathway activity biomarkers of AT-7519 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of mitotic cell cycle phase transition →	+0.957	+0.953	.016	.033	3	8
KIDNEY	RNA polymerase I preinitiation complex assembly →	+0.787	+0.705	.035	.038	3	7
BLOOD_Leukemia	Positive regulation of transporter activity →	-0.426	-0.539	.007	.004	3	7
SOFT_TISSUE	Negative regulation of immune effector process →	-0.379	-1.301	<.001	<.001	3	7
STOMACH	Regulation of cell fate specification →	+0.994	+0.652	.028	.010	3	7
PANCREAS	NLS-bearing protein import into nucleus →	+0.314	+0.583	.002	.011	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AT-7519 response vs Positive regulation of mitotic cell cycle phase transition — STOMACH

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