AST-1306

Across CCLE and GDSC cell-line panels, response to AST-1306 is significantly associated with the RNA expression of multiple genes, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible AST-1306 response-associated genes across cancer lineages are GHITM, PATZ1, and RHOB, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AST-1306 response versus GHITM RNA expression in BLOOD_Leukemia (Pearson r = -0.35).

Rna expression biomarkers of AST-1306 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHITM →	-0.630	-0.437	.002	.007	3	7
BLOOD_Lymphoma	PATZ1 →	+0.995	+0.548	.002	<.001	3	7
LUNG_NSCLC_LUSC	RHOB →	+1.649	+0.364	.035	.004	3	7
STOMACH	LYRM1 →	-1.161	-1.075	.007	.012	3	7
BREAST	SLC47A1 →	-1.185	-0.575	.005	.008	3	7
LIVER	SLC7A11 →	-1.805	-0.625	.043	.010	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AST-1306 response vs GHITM — BLOOD_Leukemia

Explore this scatter interactively →