ARRY-520

Across CCLE and GDSC cell-line panels, response to ARRY-520 is significantly associated with the shRNA pathway dependency of multiple pathways, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible ARRY-520 response-associated pathways across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Cell cycle G2/M phase transition, and Pericardium morphogenesis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ARRY-520 response versus Positive regulation of anaphase-promoting complex-dependent catabolic process shRNA pathway dependency in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.68).

Shrna pathway dependency biomarkers of ARRY-520 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+1.473	+1.573	.033	.038	3	7
LUNG_NSCLC_LUSC	Cell cycle G2/M phase transition →	-0.195	-1.379	<.001	.002	3	7
BONE	Pericardium morphogenesis →	-1.344	-0.453	.001	.033	3	7
LUNG_NSCLC_LUSC	Endoplasmic reticulum localization →	+1.557	+1.267	.002	.008	3	6
LUNG_NSCLC_LUSC	G2/M transition of mitotic cell cycle →	-0.204	-1.379	.001	.002	3	6
BLOOD_Lymphoma	Response to muscle inactivity →	-1.853	-1.853	.001	.002	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARRY-520 response vs Positive regulation of anaphase-promoting complex-dependent catabolic process — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →