AMG-319

Across CCLE and GDSC cell-line panels, response to AMG-319 is significantly associated with the total protein of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible AMG-319 response-associated proteins across cancer lineages are Rad50, p27_pT198, and PDK1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AMG-319 response versus Rad50 total protein in STOMACH (Pearson r = -0.41).

Total protein biomarkers of AMG-319 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Rad50 →	-0.754	-0.358	.003	.003	2	7
STOMACH	p27_pT198 →	+0.219	+0.405	.004	.035	3	5
BLOOD_Myeloma	PDK1 →	-0.485	-0.429	.007	.015	3	5
STOMACH	E-Cadherin →	-1.908	-0.285	.023	.039	3	5
SKIN	b-Actin →	+0.979	+0.404	.006	.014	3	5
UPPER_AERODIGESTIVE_TRACT	Lck →	-0.905	-0.411	<.001	<.001	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMG-319 response vs Rad50 — STOMACH

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