AMG-319

Across CCLE and GDSC cell-line panels, response to AMG-319 is significantly associated with the protein abundance of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible AMG-319 response-associated proteins across cancer lineages are F11R, ATRN, and HNRNPUL2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AMG-319 response versus F11R protein abundance in OVARY (Pearson r = -0.43).

Protein abundance biomarkers of AMG-319 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	F11R →	-1.346	-0.493	.009	.003	3	8
BLOOD_Lymphoma	ATRN →	-1.437	-0.396	.003	.018	3	8
STOMACH	HNRNPUL2 →	-0.772	-0.490	.011	.008	2	8
BONE	SARS1 →	+1.160	+0.282	.004	.036	3	7
LUNG_NSCLC_LUSC	NARS1 →	+1.014	+0.432	.019	.022	3	7
STOMACH	NRP1 →	+1.958	+0.568	.004	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMG-319 response vs F11R — OVARY

Explore this scatter interactively →