AMG-319

Across CCLE and GDSC cell-line panels, response to AMG-319 is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible AMG-319 response-associated pathways across cancer lineages are Rho protein signal transduction, Protein localization to cell periphery, and Regulation of ATF6-mediated unfolded protein response, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AMG-319 response versus Rho protein signal transduction pathway activity in BONE (Pearson r = -0.77).

Pathway activity biomarkers of AMG-319 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Rho protein signal transduction →	-0.150	-0.470	.004	.002	3	10
BREAST	Protein localization to cell periphery →	-0.041	-0.449	.014	.010	3	9
LARGE_INTESTINE	Regulation of ATF6-mediated unfolded protein response →	-0.129	-0.393	.014	.039	3	8
BREAST	Nucleoside bisphosphate metabolic process →	+0.072	+0.312	.012	.020	3	8
BREAST	Ribonucleoside bisphosphate metabolic process →	+0.072	+0.312	.012	.020	3	8
BREAST	Purine nucleoside bisphosphate metabolic process →	+0.072	+0.312	.012	.020	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMG-319 response vs Rho protein signal transduction — BONE

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