AICA Ribonucleotide

Across CCLE and GDSC cell-line panels, response to AICA Ribonucleotide is significantly associated with the shRNA pathway dependency of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible AICA Ribonucleotide response-associated pathways across cancer lineages are Muscle cell proliferation, Protein K11-linked deubiquitination, and Monocarboxylic acid catabolic process, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AICA Ribonucleotide response versus Muscle cell proliferation shRNA pathway dependency in LARGE_INTESTINE (Pearson r = -0.42).

Shrna pathway dependency biomarkers of AICA Ribonucleotide response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Muscle cell proliferation →	-0.666	-0.367	.010	.015	3	7
SOFT_TISSUE	Protein K11-linked deubiquitination →	+1.938	+0.863	.047	.018	3	6
LARGE_INTESTINE	Monocarboxylic acid catabolic process →	+0.588	+0.504	.035	.016	3	6
LIVER	Negative regulation of cytoskeleton organization →	-0.272	-0.786	.003	.002	3	6
BLOOD_Myeloma	Regulation of cellular response to oxidative stress →	-1.752	-0.487	<.001	.004	3	6
BLOOD_Leukemia	tRNA aminoacylation for mitochondrial protein translation →	-1.304	-0.509	.002	.003	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AICA Ribonucleotide response vs Muscle cell proliferation — LARGE_INTESTINE

Explore this scatter interactively →