ACY-1215

Across CCLE and GDSC cell-line panels, response to ACY-1215 is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible ACY-1215 response-associated gene dependencies across cancer lineages are UBE2O, LTBP1, and RFX5, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ACY-1215 response versus UBE2O shRNA dependency in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Shrna dependency biomarkers of ACY-1215 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UBE2O →	+0.268	+0.871	.005	.009	3	7
CNS	LTBP1 →	-0.240	-0.588	.042	.012	3	7
SOFT_TISSUE	RFX5 →	-0.219	-0.844	.013	.017	3	7
CNS	ZNF768 →	+0.178	+0.625	.010	.009	3	7
KIDNEY	THOC5 →	-0.375	-0.547	.004	.017	2	8
URINARY_TRACT	AQP4 →	+0.300	+0.460	.001	.011	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACY-1215 response vs UBE2O — LUNG_NSCLC_LUSC

Explore this scatter interactively →