ACY-1215

Across CCLE and GDSC cell-line panels, response to ACY-1215 is significantly associated with the pathway activity of multiple pathways, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible ACY-1215 response-associated pathways across cancer lineages are Necroptotic process, Chondroblast differentiation, and Alkaloid metabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ACY-1215 response versus Necroptotic process pathway activity in OESOPHAGUS (Pearson r = -0.50).

Pathway activity biomarkers of ACY-1215 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Necroptotic process →	-0.062	-0.331	.013	.010	3	9
BONE	Chondroblast differentiation →	-2.078	-0.632	<.001	.024	3	9
KIDNEY	Alkaloid metabolic process →	-0.135	-1.087	.002	.006	3	9
KIDNEY	Regulation of fatty acid metabolic process →	-0.063	-0.810	.005	.005	3	8
CNS	Negative regulation of cytokine production →	-0.062	-0.507	.002	.002	3	8
LUNG_SCLC	Host-mediated perturbation of viral transcription →	+0.096	+0.357	.002	.012	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACY-1215 response vs Necroptotic process — OESOPHAGUS

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