ABT737

Across CCLE and GDSC cell-line panels, response to ABT737 is significantly associated with the protein abundance of multiple proteins, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible ABT737 response-associated proteins across cancer lineages are HDHD2, GNG12, and MYH14, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ABT737 response versus HDHD2 protein abundance in SOFT_TISSUE (Pearson r = 0.50).

Protein abundance biomarkers of ABT737 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HDHD2 →	+1.114	+0.934	.025	.029	2	9
BONE	GNG12 →	-2.207	-0.801	.001	<.001	3	8
LUNG_NSCLC_LUAD	MYH14 →	+0.740	+0.399	.006	.001	3	7
SOFT_TISSUE	EMD →	-0.832	-0.659	<.001	.005	3	7
BLOOD_Myeloma	CERS2 →	-1.431	-1.404	.003	.002	3	7
SOFT_TISSUE	M6PR →	-0.830	-0.613	.020	.041	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABT737 response vs HDHD2 — SOFT_TISSUE

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