ABT737

Across CCLE and GDSC cell-line panels, response to ABT737 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible ABT737 response-associated pathways across cancer lineages are Negative regulation of execution phase of apoptosis, Host-mediated activation of viral process, and Spliceosomal conformational changes to generate catalytic conformation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ABT737 response versus Negative regulation of execution phase of apoptosis shRNA pathway dependency in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Shrna pathway dependency biomarkers of ABT737 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of execution phase of apoptosis →	+0.422	+1.280	.007	.009	3	8
BONE	Host-mediated activation of viral process →	+0.447	+1.479	.009	.005	3	8
OESOPHAGUS	Spliceosomal conformational changes to generate catalytic conformation →	+0.196	+0.643	.032	.038	2	8
LUNG_NSCLC_LUSC	Negative regulation of membrane permeability →	+2.173	+1.226	.006	.007	3	7
OVARY	Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway →	+1.805	+0.848	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Regulation of phosphatidylinositol dephosphorylation →	+0.879	+0.504	<.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABT737 response vs Negative regulation of execution phase of apoptosis — LUNG_NSCLC_LUSC

Explore this scatter interactively →