A-83-01

Across CCLE and GDSC cell-line panels, response to A-83-01 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible A-83-01 response-associated pathways across cancer lineages are Response to psychosocial stress, Negative regulation of receptor signaling pathway via STAT, and Negative regulation of viral genome replication, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, A-83-01 response versus Response to psychosocial stress shRNA pathway dependency in LUNG_NSCLC_LUSC (Pearson r = 0.71).

Shrna pathway dependency biomarkers of A-83-01 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to psychosocial stress →	+1.318	+0.510	.003	<.001	3	7
BLOOD_Leukemia	Negative regulation of receptor signaling pathway via STAT →	-1.231	-0.394	.003	.013	3	7
LUNG_NSCLC_LUAD	Negative regulation of viral genome replication →	+0.978	+0.397	.002	.003	3	7
BONE	Response to yeast →	-1.923	-0.464	<.001	.030	3	6
LUNG_NSCLC_LUSC	Negative regulation of smoothened signaling pathway →	-0.192	-0.620	.024	.013	3	6
SOFT_TISSUE	Positive regulation of mRNA catabolic process →	+0.258	+0.556	.047	.010	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A-83-01 response vs Response to psychosocial stress — LUNG_NSCLC_LUSC

Explore this scatter interactively →