A-366

Across CCLE and GDSC cell-line panels, response to A-366 is significantly associated with the shRNA dependency of multiple gene dependencies, with CNS cell lines showing a particularly strong set of associations.

The most reproducible A-366 response-associated gene dependencies across cancer lineages are B3GALT4, C1QBP, and USF2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, A-366 response versus B3GALT4 shRNA dependency in CNS (Pearson r = -0.71).

Shrna dependency biomarkers of A-366 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	B3GALT4 →	-0.198	-0.589	.012	.029	3	8
URINARY_TRACT	C1QBP →	+0.222	+0.493	.035	.024	3	7
BLOOD_Leukemia	USF2 →	+0.254	+0.532	.001	.022	3	7
BONE	NEB →	+0.165	+0.372	.003	.014	3	6
BLOOD_Lymphoma	NDUFA3 →	+0.450	+0.563	.020	.040	3	6
STOMACH	GJB3 →	-0.171	-0.422	.049	.019	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A-366 response vs B3GALT4 — CNS

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