993-D2

Across CCLE and GDSC cell-line panels, response to 993-D2 is significantly associated with the protein abundance of multiple proteins, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible 993-D2 response-associated proteins across cancer lineages are FTL, USP10, and PIP4P1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 993-D2 response versus FTL protein abundance in LUNG_NSCLC_LUAD (Pearson r = -0.33).

Protein abundance biomarkers of 993-D2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FTL →	-1.211	-0.338	.033	.025	3	7
BLOOD_Myeloma	USP10 →	+0.993	+0.296	.005	.017	3	7
LUNG_SCLC	PIP4P1 →	-0.892	-0.241	.032	.011	3	7
OESOPHAGUS	CRYZ →	-0.885	-0.352	.004	.025	3	7
SOFT_TISSUE	PRDX5 →	-0.935	-0.297	<.001	.003	3	7
PANCREAS	CEBPE →	-1.097	-0.517	.036	.032	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

993-D2 response vs FTL — LUNG_NSCLC_LUAD

Explore this scatter interactively →