776928

Across CCLE and GDSC cell-line panels, response to 776928 is significantly associated with the protein abundance of multiple proteins, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible 776928 response-associated proteins across cancer lineages are RHOC, RBBP4, and ANXA4, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 776928 response versus RHOC protein abundance in SOFT_TISSUE (Pearson r = -0.64).

Protein abundance biomarkers of 776928 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RHOC →	-2.127	-1.358	<.001	.002	3	8
STOMACH	RBBP4 →	+0.666	+0.423	.032	.035	2	9
OVARY	ANXA4 →	-3.025	-0.852	<.001	.001	3	8
PANCREAS	RPL9 →	+0.680	+0.931	.027	.013	3	8
BLOOD_Lymphoma	PSAP →	-1.296	-0.242	.008	.014	3	8
SOFT_TISSUE	GATAD2A →	+0.937	+0.871	.006	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

776928 response vs RHOC — SOFT_TISSUE

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