765771

Across CCLE and GDSC cell-line panels, response to 765771 is significantly associated with the RNA expression of multiple genes, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible 765771 response-associated genes across cancer lineages are FRAT2, TOMM6, and ABTB2, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 765771 response versus FRAT2 RNA expression in BLOOD_Myeloma (Pearson r = 0.43).

Rna expression biomarkers of 765771 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FRAT2 →	+0.922	+0.697	.043	.024	3	9
KIDNEY	TOMM6 →	+1.342	+0.805	.043	.001	3	9
BLOOD_Lymphoma	ABTB2 →	-2.009	-0.646	.001	.001	3	9
LUNG_NSCLC_LUSC	CREB3 →	-1.173	-0.902	.004	.024	2	10
BLOOD_Leukemia	CCSER2 →	-1.170	-0.489	.005	.006	3	8
BLOOD_Myeloma	OTX1 →	+0.995	+0.794	.007	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

765771 response vs FRAT2 — BLOOD_Myeloma

Explore this scatter interactively →