765771

Across CCLE and GDSC cell-line panels, response to 765771 is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible 765771 response-associated pathways across cancer lineages are Intracellular calcium ion homeostasis, Myofibril assembly, and rRNA 5'-end processing, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 765771 response versus Intracellular calcium ion homeostasis protein-level pathway activity in OVARY (Pearson r = -0.54).

Protein-level pathway activity biomarkers of 765771 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Intracellular calcium ion homeostasis →	-0.220	-0.364	.001	.014	3	10
LUNG_NSCLC_LUSC	Myofibril assembly →	-0.542	-0.899	.042	.022	3	9
LUNG_NSCLC_LUSC	rRNA 5'-end processing →	+1.745	+0.902	.008	.021	3	8
LUNG_NSCLC_LUAD	Synaptic membrane adhesion →	-0.509	-0.514	.031	.044	3	8
SOFT_TISSUE	Phagocytosis, engulfment →	-0.267	-0.547	.035	.048	3	8
SOFT_TISSUE	Regulation of protein localization to plasma membrane →	-0.227	-0.506	.014	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

765771 response vs Intracellular calcium ion homeostasis — OVARY

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