741909

Across CCLE and GDSC cell-line panels, response to 741909 is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible 741909 response-associated genes across cancer lineages are VCAN, PTPN13, and DMXL2, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, 741909 response grouped by VCAN status in LUNG_NSCLC_LUSC.

Mutation status biomarkers of 741909 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VCAN →	+2.321	+0.353	.047	.046	3	3
LARGE_INTESTINE	PTPN13 →	+2.807	+0.564	.035	.011	3	3
LARGE_INTESTINE	DMXL2 →	+3.169	+0.503	.005	.014	3	3
LARGE_INTESTINE	SACS →	+1.874	+0.410	.009	.033	3	3
LARGE_INTESTINE	FAT4 →	+1.378	+0.555	.007	.003	3	3
LARGE_INTESTINE	MUC19 →	+2.710	+0.533	.027	.007	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

741909 response by VCAN status — LUNG_NSCLC_LUSC

Explore this box plot interactively →