741909

Across CCLE and GDSC cell-line panels, response to 741909 is significantly associated with the pathway activity of multiple pathways, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible 741909 response-associated pathways across cancer lineages are Regulation of integrin-mediated signaling pathway, Epinephrine metabolic process, and Response to vitamin K, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 741909 response versus Regulation of integrin-mediated signaling pathway pathway activity in KIDNEY (Pearson r = -0.57).

Pathway activity biomarkers of 741909 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of integrin-mediated signaling pathway →	-0.134	-1.322	.035	.031	3	8
LUNG_NSCLC_LUAD	Epinephrine metabolic process →	+0.497	+0.716	.019	.001	3	8
BONE	Response to vitamin K →	-2.282	-1.074	<.001	.015	3	7
BONE	Sulfur amino acid biosynthetic process →	+0.156	+0.917	.020	.001	3	7
LIVER	Catecholamine metabolic process →	+0.278	+0.830	.018	.016	3	7
LIVER	Catechol-containing compound metabolic process →	+0.278	+0.830	.018	.016	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

741909 response vs Regulation of integrin-mediated signaling pathway — KIDNEY

Explore this scatter interactively →