729189

Across CCLE and GDSC cell-line panels, response to 729189 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible 729189 response-associated pathways across cancer lineages are Forebrain generation of neurons, Regulation of cell maturation, and Glucose 6-phosphate metabolic process, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 729189 response versus Forebrain generation of neurons shRNA pathway dependency in LUNG_SCLC (Pearson r = 0.53).

Shrna pathway dependency biomarkers of 729189 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Forebrain generation of neurons →	+0.459	+0.262	.003	.034	3	7
SKIN	Regulation of cell maturation →	+1.264	+0.321	.001	.016	3	7
SOFT_TISSUE	Glucose 6-phosphate metabolic process →	-1.768	-0.139	<.001	<.001	3	7
BREAST	Indole-containing compound catabolic process →	+0.925	+0.327	.001	.015	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of defense response to bacterium →	-1.527	-0.276	.001	.026	3	6
SKIN	Regulation of defense response to bacterium →	-1.099	-0.261	.006	.022	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

729189 response vs Forebrain generation of neurons — LUNG_SCLC

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