667880

Across CCLE and GDSC cell-line panels, response to 667880 is significantly associated with the shRNA pathway dependency of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible 667880 response-associated pathways across cancer lineages are Apoptotic cell clearance, Negative regulation of type I interferon production, and Pyruvate decarboxylation to acetyl-CoA, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 667880 response versus Apoptotic cell clearance shRNA pathway dependency in LIVER (Pearson r = -0.36).

Shrna pathway dependency biomarkers of 667880 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Apoptotic cell clearance →	-1.515	-1.113	.048	.043	2	8
URINARY_TRACT	Negative regulation of type I interferon production →	-0.200	-0.983	.046	.031	3	7
LIVER	Pyruvate decarboxylation to acetyl-CoA →	+1.751	+1.019	<.001	.005	3	7
LIVER	Biological process involved in symbiotic interaction →	-0.215	-0.892	.036	.023	3	7
PANCREAS	Regulation of T cell migration →	-1.362	-0.804	<.001	.003	3	6
SKIN	Regulation of lamellipodium assembly →	-0.599	-0.595	.015	.015	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

667880 response vs Apoptotic cell clearance — LIVER

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