5-Fluorouracil

Across CCLE and GDSC cell-line panels, response to 5-Fluorouracil is significantly associated with the protein-level pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible 5-Fluorouracil response-associated pathways across cancer lineages are Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Epithelial cell development, and Nuclear-transcribed mRNA catabolic process, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 5-Fluorouracil response versus Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein-level pathway activity in LARGE_INTESTINE (Pearson r = 0.39).

Protein-level pathway activity biomarkers of 5-Fluorouracil response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.224	+0.591	.005	.004	3	10
LARGE_INTESTINE	Epithelial cell development →	-0.246	-0.773	.003	.003	3	9
PANCREAS	Nuclear-transcribed mRNA catabolic process →	+0.222	+0.862	.002	.015	3	9
BLOOD_Lymphoma	Negative regulation of D-glucose transmembrane transport →	-0.940	-0.625	<.001	.002	3	9
STOMACH	Negative regulation of NLRP3 inflammasome complex assembly →	-0.172	-0.774	.014	.015	3	9
KIDNEY	Microtubule-based transport →	-0.144	-0.789	.009	.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

5-Fluorouracil response vs Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay — LARGE_INTESTINE

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