150412

Across CCLE and GDSC cell-line panels, response to 150412 is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible 150412 response-associated proteins across cancer lineages are PTPN1, NCEH1, and ACOT8, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 150412 response versus PTPN1 protein abundance in LUNG_SCLC (Pearson r = -0.59).

Protein abundance biomarkers of 150412 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTPN1 →	-1.311	-0.527	<.001	.004	3	10
SOFT_TISSUE	NCEH1 →	-4.294	-0.492	.001	.030	3	9
BLOOD_Leukemia	ACOT8 →	-0.954	-0.259	.002	.030	2	10
LIVER	CHD4 →	+0.575	+1.297	.008	.015	3	8
LUNG_SCLC	MBOAT7 →	-1.204	-0.402	.010	.029	3	8
BONE	GRWD1 →	+0.808	+0.425	.023	.008	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

150412 response vs PTPN1 — LUNG_SCLC

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