123829

Across CCLE and GDSC cell-line panels, response to 123829 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible 123829 response-associated genes across cancer lineages are ABCA8, NACA, and LAMA5, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, 123829 response grouped by ABCA8 status in LARGE_INTESTINE.

Mutation status biomarkers of 123829 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ABCA8 →	+3.523	+0.805	<.001	<.001	3	3
LARGE_INTESTINE	NACA →	+2.386	+0.689	.007	.003	3	3
BONE	LAMA5 →	+2.672	+0.566	.039	.042	3	2
BREAST	OBSCN →	+2.321	+0.472	.006	.028	3	2
LARGE_INTESTINE	ARID1A →	+2.286	+0.816	<.001	<.001	3	2
BLOOD_Lymphoma	CSMD3 →	-2.321	-0.378	.010	.043	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

123829 response by ABCA8 status — LARGE_INTESTINE

Explore this box plot interactively →